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Changes in tRNA wobble modifications under a norepinephrine gradient coincide with codon-biased translation and induction of virulence in EHEC O157:H7

ABSTRACT: The goal of this study was to investigate how Enterohemorrhagic Escherichia coli O157:H7 (EHEC) strain EDL933 remodels its tRNA pool in response to the catecholamine hormone norepinephrine, a host-derived cue that stimulates virulence in this pathogen. Here, we performed Absolute Quantitative RNA-sequencing (AQRNA-seq) to measure levels of tRNA isoacceptors in EHEC samples exposed to 0, 25, and 50 micromolar norepinephrine.

ORGANISM(S): Escherichia coli

PROVIDER: GSE309283 | GEO | 2026/04/17

REPOSITORIES: GEO

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Changes in tRNA wobble modifications under a norepinephrine gradient coincide with codon-biased translation and induction of virulence in EHEC O157:H7

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