Baseline and Follow-up Methylation Profiling of Whole Blood DNA in Normoglycemia, Prediabetes, and Type 2 Diabetes

ABSTRACT: This longitudinal study analyzed whole-blood DNA methylation profiles in adults classified as normoglycemic, prediabetic, or type 2 diabetes mellitus (T2DM). Oxford Nanopore PromethION long-read sequencing (PCR-free ligation preparation) was used to generate genome-wide CpG methylation data at baseline and at six-year follow-up. The dataset includes raw nanopore reads (available in SRA) and processed methylation outputs, including CpG-wise differential methylation, methylation summaries, promoter/CpG island annotation, HOMER functional annotation, and gene–pathway mapping

ORGANISM(S): Homo sapiens

PROVIDER: GSE311226 | GEO | 2026/04/20

REPOSITORIES: GEO