Effect of BMP2, BMP3, BMP4, IL6, LIF, and OSM on the gene expression profiles of two patient-derived glioblastoma neurosphere lines.

ABSTRACT: To identify microenvironmental influences on glioblastoma (GBM) cell death response, a secreted factor modulatory screen was conducted on primary patient-derived GBM neurospheres. This screen identified several protein ligands that broadly altered GBM cell death response. To gain a better understanding of the mechanisms by which they alter cell death, we performed RNA-seq on the neurospheres following exogenous addition of the protein ligands.

ORGANISM(S): Homo sapiens

PROVIDER: GSE312023 | GEO | 2026/06/01

REPOSITORIES: GEO