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MAPK- driven glioma progression and reprogramming of the tumor-associated immune response

ABSTRACT: Glioma evolution is associated with disease progression and therapeutic resistance. We recently identified a group of MAPK-driven glioma with CDKN2A homozygous deletion that are low-grade and immune enriched. However, Over time, these tumors can progress to aggressive, higher-grade tumors. While low-grade tumors may be amenable to immunotherapeutic strategies, it is unknown how the tumor and its microenvironment evolve.

ORGANISM(S): Homo sapiens

PROVIDER: GSE312124 | GEO | 2026/07/16

REPOSITORIES: GEO

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