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Single cell RNA and DNA profiling of aged rat kidney

ABSTRACT: We have employed a novel technology based on 10X platform to simultaneously detect DNA and expression following nucleosome depletion (DEFND-seq) to kidney cortex samples of rats from different age groups. This study characterized somatic copy number alteration of rat chromosomes during aging and associated gene expression changes during aging, especially in an injured proximal tubule cell population.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE312213 | GEO | 2026/04/12

REPOSITORIES: GEO

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Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease

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