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Betulonic acid alleviates dexamethasone-induced MC3T3-E1 osteoblast injury: a transcriptomic sequencing analysis

ABSTRACT: Steroid-induced osteonecrosis of the femoral head(SONFH) is a severe complication of glucocorticoid therapy, with oxidative stress playing a pivotal role in its pathogenesis. Betulonic acid (BA), a natural triterpenoid, exhibits antioxidant properties; however, its role in SONFH remains unclear. This study aimed to investigate the protective effect of BA against dexamethasone (DEX)-induced osteoblast injury and its underlying molecular mechanisms.Three experimental groups were established: control (NC), dexamethasone treatment group(DEX), and dexamethasone plus BA co-treatment group(DEX_BA), each with three biological replicates.

ORGANISM(S): Mus musculus

PROVIDER: GSE312690 | GEO | 2026/09/10

REPOSITORIES: GEO

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