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Spatial transcriptomic profiling (Visium) of meningioma

ABSTRACT: We applied spatial transcriptomic profiling (10x Genomics Visium) to meningioma samples across grades and methylation classes, in order to characterize features of meningioma heterogeneity across subgroups. We identified an overall decrease in myeloid cell proportions from grade 1 to grade 3 meningiomas, as well as a phenotypic shift from microglia-like cells towards a myeloid-derived proliferative macrophage phenotype.

ORGANISM(S): Homo sapiens

PROVIDER: GSE313694 | GEO | 2025/12/23

REPOSITORIES: GEO

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