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NanoString profiling of IRF3 and IRF7 deficient macrophages and dendritic cells during influenza infection

ABSTRACT: Interferon regulatory factors IRF3 and IRF7 are key transcriptional regulators of antiviral immune responses. However, their cell type–specific roles in macrophages and dendritic cell subsets during influenza virus infection remain incompletely understood. In this study, NanoString nCounter gene expression profiling was performed to systematically characterize transcriptional responses in alveolar macrophages (AM), conventional dendritic cells type 1 (DC1), and type 2 (DC2). Wild-type and IRF3- or IRF7-deficient cells were analyzed under uninfected and influenza-infected conditions. This dataset enables comparative analysis of IRF3- and IRF7-dependent gene expression programs across immune cell types and infection states, providing a resource for dissecting distinct antiviral and inflammatory regulatory mechanisms.

ORGANISM(S): Mus musculus

PROVIDER: GSE313762 | GEO | 2026/02/18

REPOSITORIES: GEO

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