Transcriptomics

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Aortic Single-Cell Transcriptome Analysis Reveals ApoE Isoform-Specific Effects in Vascular Disease Modulation


ABSTRACT: The human APOE gene is polymorphic with 3 major alleles that encode apolipoprotein (apo) E2, apoE3, and apoE4. Both apoE2 and apoE4 are associated with increased atherosclerosis risk. This study uses Human APOE2, APOE3, and APOE4 gene replacement mice and scRNA-seq to delineate the mechanisms underlying this association, with a focus on how the various apoE isoforms influence the cell repertoire in the vessel wall.

ORGANISM(S): Mus musculus

PROVIDER: GSE314969 | GEO | 2026/07/01

REPOSITORIES: GEO

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