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Characterization of the N- and C-terminal domain interface of the three main apoE isoforms

ABSTRACT: Chemical cross-linking coupled to mass spectrometry was used to investigate the conformations of the apolipoprotein isoforms apoE2, apoE3, and apoE4. Cross-linking data was generated using the reagents disuccinimidyl suberate (DSS), pimelic dihydrazide (PDH), and 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium (DMTMM) chloride. Intramolecular interactions derived from the cross-linking experiments were combined with molecular modeling approaches.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Alexander Leitner

LAB HEAD: Alexander Leitner

PROVIDER: PXD025710 | Pride | 2025-01-26

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	ApoE_file_list_PRIDE.xlsx	Xlsx
	Results_in_gel_dig.xlsx	Xlsx
	Results_in_solution_dig.xlsx	Xlsx
	checksum.txt	Txt
	mazadeh_C1509_001.raw	Raw

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