Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Alexander Leitner
LAB HEAD: Alexander Leitner
PROVIDER: PXD027213 | Pride | 2021-11-23
REPOSITORIES: Pride
Nature 20211220 7899
Depolarizing sodium (Na<sup>+</sup>) leak currents carried by the NALCN channel regulate the resting membrane potential of many neurons to modulate respiration, circadian rhythm, locomotion and pain sensitivity<sup>1-8</sup>. NALCN requires FAM155A, UNC79 and UNC80 to function, but the role of these auxiliary subunits is not understood<sup>3,7,9-12</sup>. NALCN, UNC79 and UNC80 are essential in rodents<sup>2,9,13</sup>, and mutations in human NALCN and UNC80 cause severe developmental and neurol ...[more]