Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic profiling of zebrafish mutants for orthologs of genes that increase schizophrenia risk

ABSTRACT: In this study, we used CRISPR/Cas9 to knock out multiple orthologs of genes that increase risk for schizophrenia in humans. Gene sets included those from SCHEMA (exome sequencing), copy number variatns, and de novo mutations in childhood onset schizophrenia. Larval brain activity and behavior as assessed for all lines. The truncating sp4 and atp1a3a-v139m point mutation were selected for transcriptomic analysis.

ORGANISM(S): Danio rerio

PROVIDER: GSE314974 | GEO | 2026/02/16

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptomic profiling of zebrafish mutants for orthologs of genes that increase schizophrenia risk

Project description:Transcriptomic profiling of zebrafish mutants for orthologs of genes that increase schizophrenia risk

| PRJNA1393358 | ENA

Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus

Project description:Schizophrenia is a severe mental illness with high heritability, but its underlying mechanisms are poorly understood. We meta-analyzed large-scale brain transcriptomic data from mice harboring individual loss-of-function mutations in seven schizophrenia risk genes (Akap11, Dagla, Gria3, Grin2a, Sp4, Srrm2, Zmym2). While all studied brain regions were affected, the striatum and the thalamus emerged as key brain regions of convergence. Striatum showed downregulation of synapse- and oxidative phosphorylation-related gene sets in all models. In the thalamus, mutants separated into two groups based on transcriptomic phenotype: synapse-related gene sets were upregulated in mutants with only schizophrenia and bipolar association, and were downregulated in mutants that are associated with developmental delay/intellectual disability in addition to schizophrenia. Overall, our meta-analysis reveals convergence and divergence in brain transcriptomic phenotype in these schizophrenia genetic models, supports the involvement of striatal disturbance and synapse dysfunction in schizophrenia, and points to a key role of the thalamus.

2025-08-29 | GSE299704 | GEO

Genome-wide analysis of gene expression in wild-type and Sp4 hypomorphic mouse cerebellum

Project description:Transcription factor Sp4 controls dendritic patterning during development of cerebellar granule neurons in culture by limiting branch formation and promoting activity-dependent pruning (Ramos et al., 2007). Sp4 is associated with neuropsychiatric disorders such as major depressive disorder, schizophrenia and bipolar disorder. In order to identify target genes of Sp4, we compared global gene expression in the cerebella of wild type and Sp4 hypomorph mice (Sp4neo-/-; Zhou et al, 2005). The results identify candidate Sp4 target genes that may contribute to neuronal development and neuropsychiatric disorders.

2014-11-27 | GSE53061 | GEO

Genomic Microarray data from two siblings affected with Schizophrenia

Project description:Schizophrenia is a polygenic, multifactorial chronic neuropsychiatric disorde. Due to its polygenic and complex nature, traditional genetic approaches like GWAS or candidate gene studies are often insufficient to capture rare or novel mutations. We have used genomic microarray to find large deletion in the Schizophrenic patients which are difficult to find from whole exome sequencing

2025-11-25 | GSE296773 | GEO

G3BP orthologs interactional network

Project description:G3BP orthologs interactional network in humans and species.

2024-08-08 | PXD054692 |

Schizophrenia metagenome

Project description:Schizophrenia metagenome

| PRJEB29415 | ENA

Using brain cell type-specific protein interactomes to interpret genetic data in schizophrenia

Project description:Hsu Y, Nacu E, Liu R, Kim A, Tsafou K, Petrossian N, Crotty W, Suh JM, Pintacuda G, Riseman J, Martin J, Malolepsza E, Li T, Singh T, Ge T, Egri SB, Tanenbaum B, Stanclift CR, Apffel AM, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives, Carr SA, Schenone M, Jaffe J, Fornelos N, Huang H, Eggan KC, Lage K. 2021. Genetics have nominated many schizophrenia risk genes that lack functional interpretation. To empower such interpretation, we executed interaction proteomics for six risk genes in human induced neurons and found the resulting protein network to be enriched for common variant risk of schizophrenia in Europeans and East Asians. The network is down-regulated in layer 5/6 cortical neurons of patients and can complement fine-mapping and eQTL data to prioritize additional genes in GWAS loci. A sub-network centered on HCN1 is enriched for common variant risk and also contains proteins (HCN4 and AKAP11) enriched for rare protein-truncating mutations in patients with schizophrenia and bipolar disease. Our findings establish brain cell-type-specific interactomes as an organizing framework to facilitate interpretation of genetic and transcriptomic data in schizophrenia and psychiatric diseases.

2021-05-25 | MSV000087514 | MassIVE

Schizophrenia monocytes

Project description:Schizophrenia is a severe psychiatric disorder. Another study in BD has shown an aberrant pro-inflammatory status of monocytes/macrophages. Therefore, this study aimed at studying the monocyte compartment in schizophrenia, by transcription profiling of CD14+ monocytes in patients and controls.

2010-11-20 | E-MEXP-2998 | biostudies-arrayexpress

Schizophrenia Targeted Sequencing

Project description:Schizophrenia Targeted Sequencing

| PRJEB9045 | ENA

Saudi Schizophrenia

Project description:CNV Screening of Saudi Schizophrenia

| PRJEB57402 | ENA