Project description:The RNA was extracted from post-mortem cortical grey matter of STG from the left hemisphere of 9 pairs of male subjects with schizophrenia and matched non-psychiatric controls. Each sample was subjected to 76 cycles of sequencing from a single end in one lane of Illumina Genome Analyzer II.
Project description:We use NGS to assess the ability of TALE-guided DNA methyltranferases to make targeted changes to DNA methylation Targeted bisulfite sequencing of cells infected with wild-type or mutant TALE-DNMT constructs directed to the CDKN2A (p16) locus
Project description:Schizophrenia is a severe psychiatric disorder. Another study in BD has shown an aberrant pro-inflammatory status of monocytes/macrophages. Therefore, this study aimed at studying the monocyte compartment in schizophrenia, by transcription profiling of CD14+ monocytes in patients and controls.