Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-cell RNA sequencing of primary colorectal cancer, matched adjacent normal tissues, and paired liver metastases

ABSTRACT: This study will perform single-cell RNA sequencing on primary tumor tissues (T) and matched adjacent non-tumor tissues (N) from six colorectal cancer patients, along with paired liver metastatic lesions (M) from three of these patients, to construct an integrated single-cell atlas spanning primary tumors, adjacent normal tissues, and distant metastases. This multi-region, patient-matched design enables systematic dissection of cellular heterogeneity, dynamic immune responses, and key molecular mechanisms driving metastasis in colorectal cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE315534 | GEO | 2026/04/02

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	GSE315534_RAW.tar	Raw
	filelist.txt	Txt

Items per page:

1 - 3 of 3

Similar Datasets

microRNA expression profiling among WTX low human colorectal cancer tissues and matched adjacent WTX high normal colorectal mucosa

Project description:Comparing to matched normal mucosa, WTX was lost in most of human colorectal cancers (Zhang et al., 2016). We analyzed the microRNA expression profiling among WTX low human colorectal cancer tissues and matched adjacent WTX high normal colorectal mucosa. The aimed to identify the unique signature of miRNAs which related to WTX loss in human colorectal cancers.

2017-02-15 | GSE94881 | GEO

microRNA expression profiling among WTX low human gastric cancer tissues and matched adjacent WTX high normal gastric mucosa

Project description:Comparing to matched normal mucosa, WTX was lost in most of human gastric cancers (Zhang et al., 2016). We analyzed the microRNA expression profiling among WTX low human colorectal cancer tissues and matched adjacent WTX high normal colorectal mucosa. The aimed to identify the unique signature of miRNAs which related to WTX loss in human colorectal cancers.

2017-02-15 | GSE94882 | GEO

Expression data from glioblastoma tissue and matched adjacent normal tissue

Project description:Glioblastoma (GBM) is the most common and lethal primary malignancy of the central nervous system in adult. In order to improve the diagnosis, prevention and treatment of GBM, the details of molecular mechanisms underlying the tumorigenesis and development needs to be clarified. This is a nalysis of glioblastoma tissues and matched adjacent normal brain tissues from 3 patients. Results provide insight into molecular mechanisms underlying the non-coding and coding genes interactions in glioblastoma. 3 human GBM tissues and the matched adjacent normal brain tissues were analyzed using microarray. The aberrant lncRNAs, miRNAs and mRNAs between the 2 groups were detected.

2015-02-04 | GSE65626 | GEO

Cancer Samples vs. Matched Adjacent Noncancerous Samples

Project description:This SuperSeries is composed of the following subset Series: GSE33335: Expression data from gastric tissues: Cancer Samples vs. Matched Adjacent Noncancerous Samples GSE33428: Copy number variation profiling of gastric tissues: Cancer Samples vs. Matched Adjacent Noncancerous Samples Refer to individual Series

2012-05-22 | E-GEOD-33429 | biostudies-arrayexpress

Gene expression analysis of colorectal tumors and matched adjacent non-tumor colorectal tissues.

Project description:We performed gene expression profiling of 26 colorectal tumors and matched histologically normal adjacent colonic tissue samples using the Illumina Ref-8 whole-genome expression BeadChip. We performed an integrated analysis of promoter DNA methylation and gene expression data to investigate the effects of DNA hypermethylation on gene expression. Total RNA was isolated from 26 pairs of fresh frozen colorectal tumor and matched adjacent non-tumor tissue samples. Their gene expression profiles were obtained using the Illumina Ref-8 whole-genome expression BeadChip (HumanRef-8 v3.0, 24,526 transcripts).

2011-06-03 | E-GEOD-25070 | biostudies-arrayexpress

Gene expression profiling of colorectal cancer tissues, matched normal tissues, colorectal cancer cell lines, and primary cultures (2D organoids)

Project description:We performed a comprehensive gene expression analysis of human colorectal cancer (CRC) tissues, matched adjacent normal mucosa, established CRC cell lines, and primary cultures derived from patient tumors (2D organoids). This dataset aims to identify genes and signaling pathways preferentially expressed in cancer cells and to explore clinically relevant mechanisms through comparative analysis of primary cultures and patient tissues.

2025-08-20 | GSE305538 | GEO

Noncoding RNA and mRNA expression data from human colorectal cancer tissues and adjacent non-cancerous tissues

Project description:Total RNA from 6 pairs colorectal cancer tissues and its matched adjacent non-cancerous tissues was extracted and sequenced by high throughput sequencing. Then, differentially expressed circRNAs, long noncoding RNAs, and mRNAs were showed in colorectal cancer.

2023-01-18 | GSE143939 | GEO

Copy number variation profiling of gastric tissues: Cancer Samples vs. Matched Adjacent Noncancerous Samples

Project description:Copy number variation profiling of gastric tissues comparing gastric cancer tissues with matched adjacent noncancerous tissues. Goal was to determine the effects of chromosomal imbalances on gene expression and carcinogenesis or progression. 27 pairs of gastric tissues: gastric cancer tissues vs. matched adjacent noncancerous tissues.

2012-05-22 | E-GEOD-33428 | biostudies-arrayexpress

Gene expression analysis of colorectal tumors and matched adjacent non-tumor colorectal tissues.

2011-06-03 | GSE25070 | GEO

Copy number variation profiling of gastric tissues: Cancer Samples vs. Matched Adjacent Noncancerous Samples

2012-05-23 | GSE33428 | GEO