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Let-7 and lin-46 are the essential targets of the LIN28 RNA-binding protein in temporal patterning [mRNA-seq TC1]

ABSTRACT: We examined gene expression changes using mRNA-seq in two different lin-28 mutant strains, lin-28(n719) and lin-28(xe192). Although both are considered genetic null mutants, their expression profiles differ substantially: lin-28(n719) (a point mutation affecting a splice site) shows many more dysregulated genes than lin-28(xe192) (a deletion of the entire lin-28 locus).

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE315950 | GEO | 2026/06/10

REPOSITORIES: GEO

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let-7 and lin-46 are the essential targets of the LIN28 RNA-binding protein in temporal patterning [mRNA-seq TC5]

Project description:We examined mRNA levels using mRNA-seq in wild-type (N2), lin-28 mutant animals (HW2705) and animals that have the single GGAG motif (i.e. the putative LIN-28 binding motif) in the lin-46 5'UTR mutated to CTCC (HW3531).

2026-06-10 | GSE315955 | GEO

let-7 and lin-46 are the essential targets of the LIN28 RNA-binding protein in temporal patterning [mRNA-seq TC2]

Project description:We examined mRNA levels in wild-type and lin-28(xe192) animals throughout postembryonic development (0-44 h) with hourly resolution. Samples collected at 3 to 6 hours of development were used as one of the three biological replicates used to determine differentially expressed genes in lin-28(xe192) animals.

2026-06-10 | GSE315952 | GEO

let-7 and lin-46 are the essential targets of the LIN28 RNA-binding protein in temporal patterning [mRNA-seq RIPseq]

Project description:We identified 581 transcripts enriched ≥2-fold for LIN-28 binding in L1 animals.

2026-06-10 | GSE315949 | GEO

let-7 and lin-46 are the essential targets of the LIN28 RNA-binding protein in temporal patterning [mRNA-seq TC3_TC4]

Project description:We determined differentially expressed genes in lin-28(xe192) animals in the early developmental time window of 3 to 6 hours collected in three biological replicates, two included here (TC3, TC4) and one as part of a full developmental time course (TC1).

2026-06-10 | GSE315954 | GEO

let-7 and lin-46 are the essential targets of the LIN28 RNA-binding protein in temporal patterning [smallRNA-seq TC2]

Project description:We examined the levels of small RNAs in wild-type and lin-28(xe192) animals throughout postembryonic development (0-44 h) with hourly resolution. The first time points (0h to 23h) of this experiment were published previously and are accessible under the accession GSE245900 (Nahar et al. 2024). In that previous submission, all samples were sequenced twice to increase coverage (two fastq files per sample on SRA). The new samples published here (24h-44h) were only sequenced once and are thus compatible with the first sequencing round of GSE245900. While in this submission only the raw data of the new samples (24h-44h) are published, we included the time points 0h to 23h (considering only the first sequencing run, see above) in the processed data files. Due to the differences in sequencing depths between the two submissions, the intensity values for time points 0h to 23h are not identical even though they originate from the same biological samples.

2026-06-10 | GSE315956 | GEO

Effect of lin-28 and lin-46 on miRNA profile in late L1 stage Caenorhabditis elegans

Project description:Comparison of miRNA profiles of wildtype and lin-28(n719); lin-46(ma164) Caenorhabditis elegans nematodes at the L1 stage

2012-02-09 | GSE35634 | GEO

Effect of lin-28 and lin-46 on miRNA profile in late L1 stage Caenorhabditis elegans

Project description:Comparison of miRNA profiles of wildtype and lin-28(n719); lin-46(ma164) Caenorhabditis elegans nematodes at the L1 stage Two genotypes, wildtype vs. mutant. Biological replicates: 3 wild type, 3 mutant, independently grown and harvested. One replicate per slide.

2012-02-09 | E-GEOD-35634 | biostudies-arrayexpress

let-7 and lin-46 are the essential targets of the LIN28 RNA-binding protein in temporal patterning

Project description:This SuperSeries is composed of the SubSeries listed below.

2026-06-09 | GSE315957 | GEO

C. elegans LIN-28 controls temporal cell fate progression by regulating LIN-46 expression via the 5' UTR of lin-46 mRNA.

Project description: Not available

| S-EPMC8445076 | biostudies-literature

The temporal patterning system governs the malignant susceptibility of neural progeny during Drosophila development

Project description:Pediatric neural tumors are initiated during embryonic/fetal stages and rapidly become malignant despite carrying few genetic alterations. However, the molecular basis of this early malignant susceptibility remains unknown. During Drosophila development, malignant neural tumors can arise from single gene inactivation triggering dedifferentiation towards a neural stem cell (NSC)-like state. Here, we find that these tumors originate from a sub-population of early-born neural progeny that transiently co-express the mRNA-binding proteins Lin-28 and Imp/IGF2BP, and the transcription factor Chinmo. These three genes compose an early growth module that is co-opted in a subset of dedifferentiated cells to propagate unlimited proliferation. In late NSCs, Chinmo, Imp and Lin-28 are silenced by temporal transcription factors for timely termination of neurogenesis. Consequently, late-born progeny do not express the module and become refractory to malignant transformation. Thus, this study identifies the NSC-intrinsic developmental program that predisposes neural progeny to malignant transformation according to their birth order.

2017-02-09 | GSE64405 | GEO

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