Impact of Mettl1 on the transcriptional landscape of mouse bone marrow cells at single-cell resolution [scRNA-seq]

ABSTRACT: This study investigates the impact of Mettl1 deletion on the transcriptional landscape of bone marrow cells at single-cell resolution. Bone marrow mononuclear cells (BM MNCs) were collected from Mettl1+/+ Mx1-Cre and Mettl1fl/fl Mx1-Cre mice following poly(I:C)-induced recombination. Single-cell RNA sequencing (scRNA-seq) was performed using the 10x Genomics Chromium platform. The resulting data were used to identify distinct cell populations, and assess transcriptional changes associated with Mettl1 loss. This dataset provides a valuable resource for understanding the role of Mettl1 in normal hematopoiesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE316206 | GEO | 2026/07/29

REPOSITORIES: GEO