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Hepatic and adipose tissue gene expression profiles from Gpr146 wild-type and knockout male mice

ABSTRACT: Metabolic dysfunction–associated steatotic liver disease (MASLD) remains a major health burden with limited therapeutic options. Human genetic studies implicate GPR146, an orphan G protein–coupled receptor, in circulating cholesterol levels and markers of liver injury. In this study, we investigated the role of Gpr146 in mice and found that both constitutive and acute depletion of GPR146 protect against diet-induced obesity and hepatic steatosis. To understand the transcriptional basis of the phenotypes observed, we performed microarray analysis of liver and adipose tissues (epididymal white adipose tissue, inguinal white adipose tissue, and brown adipose tissue) from Gpr146 knockout and wild-type mice fed a HFD for 3 months and harvested after overnight fasting.

ORGANISM(S): Mus musculus

PROVIDER: GSE316218 | GEO | 2026/01/31

REPOSITORIES: GEO

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