A macrophage-derived noncanonical WNT niche drives immune exclusion in pancreatic cancer

ABSTRACT: We performed single-cell RNA sequencing on tumor-infiltrating cells isolated from orthotopic KPC pancreatic tumors at day 21 post-implantation. The objective was to determine how macrophage-specific ablation of WNT secretion (Csf1r-Cre;Porcnfl/fl) reshapes the PDAC immune microenvironment.

ORGANISM(S): Mus musculus

PROVIDER: GSE316305 | GEO | 2026/05/04

REPOSITORIES: GEO