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MicroRNA-224 Orchestrates the BMP Pathway and Represents a New Therapeutic Target for Pulmonary Arterial Hypertension

ABSTRACT: Mice were maintained under hypoxic conditions for 3 weeks with weekly Sugen injections and were then randomized to receive an intratracheal injection of a chemically modified antisense oligonucleotide targeting miR-224 (LNA-224) or a control antimiR (LNA-Ctrl; 5 mg/kg each) at week 3. A separate group of mice was maintained under normoxic conditions and received an intratracheal injection of LNA-Ctrl at week 3 (Nox). All mice were sacrificed at week 6, and scRNA-seq analyses were performed.

ORGANISM(S): Mus musculus

PROVIDER: GSE316584 | GEO | 2026/04/03

REPOSITORIES: GEO

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