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RNA-seq of human NK cells that were co-cultured with DU-145 cells, which were pre-treated with hIgG1 isotype, 7C6-hIgG1, or 7C6-GAALIE

ABSTRACT: 7C6 is a monoclonal antibody that inhibits the shedding of MICA and MICB, which are stress-induced ligands often expressed by tumor cells. We developed a new version of 7C6, 7C6-GAALIE, which better binds Fc gamma-activating receptors, and analyzed how it reprograms human NK cell gene expression in vitro after co-culture with a target cell line, DU-145.

ORGANISM(S): Homo sapiens

PROVIDER: GSE317314 | GEO | 2026/03/05

REPOSITORIES: GEO

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