RNA-seq analysis of rat liver under drug treatment

ABSTRACT: Epimedii Folium (EF) is widely used in traditional Chinese medicine, yet its hepatotoxic risk is increasingly recognized to be highly context dependent. This study demonstrates that EF induces significant liver injury only under conditions of immune stress, characterized by a pro-inflammatory and metabolically vulnerable hepatic state. Importantly, herb compatibility critically modulates this risk. Co-administration of Psoraleae Fructus (PF) markedly exacerbated EF-induced hepatotoxicity through amplification of inflammatory and cell death–related pathways, whereas Rhizoma Drynariae (RD) partially attenuated liver injury by stabilizing cholesterol and bile acid metabolism and restoring hepatic homeostasis

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE317736 | GEO | 2026/07/26

REPOSITORIES: GEO