A Longitudinal, Multi-omic Atlas Reveals the Emergence of a Spatially Organized Immunosuppressive Ecosystem in Resistant Melanoma

ABSTRACT: The goal of this study is to explore the mechanisms of resistance in melanoma under various immunotherapy treatments, particularly focusing on anti-PD-1 therapy, through the analysis of RPPA data. The study includes 38 tumor samples from two melanoma patients, with samples collected at pre-treatment, on-treatment, and post-treatment time points. These two patients were classified as non-responders (NRs). The RPPA data covers more than 300 antibodies targeting key signaling pathways, including hormone receptor signaling, HER family signaling, cell cycle/proliferation pathways, immune checkpoint regulation, DNA repair deficiency, AKT/mTOR/PI3K pathways, apoptosis/autophagy, IGF1R signaling, and RTK pathways. These data will serve as a valuable resource for validating resistance markers and understanding the signaling mechanisms driving tumor progression despite immune checkpoint blockade therapies.

ORGANISM(S): Homo sapiens

PROVIDER: GSE317912 | GEO | 2026/01/31

REPOSITORIES: GEO