Cellular Landscape During Ovalbumin-Induced Allergic Lung Inflammation [scRNA-Seq]

ABSTRACT: Cyclooxygenase-2 (COX-2) is a critical enzyme that helps regulate allergic responses by converting arachidonic acid (AA) into lipid-based compounds called prostaglandins (PGs), which play a key role in maintaining lung function. To better understand how COX-2-derived PGs influence allergic reactions in allergic lung inflammation, we analyzed transcriptomic changes in wild-type (COX-2+/+) and COX-2-/- mice sensitized with the allergen ovalbumin (OVA) using single-cell RNA sequencing

ORGANISM(S): Mus musculus

PROVIDER: GSE318742 | GEO | 2026/09/11

REPOSITORIES: GEO