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Transcriptomic profiling of neonatal mouse ventricular myocytes (NMVMs) under hypoxia and recombinant Serglycin stimulation

ABSTRACT: To investigate the direct regulatory effects of Serglycin (SRGN) on cardiomyocytes under ischemic conditions, we performed bulk RNA-sequencing on primary neonatal mouse ventricular myocytes (NMVMs). The study includes three experimental groups: Control (Con), Hypoxia, and Hypoxia + recombinant SRGN (rSRGN). NMVMs in the Hypoxia and Hypoxia+rSRGN groups were subjected to oxygen-glucose deprivation (glucose-free and serum-free DMEM) in an anaerobic environment (AnaeroPack-MIC, Mitsubishi A-07) for 6 hours. This dataset identifies the transcriptional alterations driven by SRGN in cardiomyocytes during hypoxic stress.

ORGANISM(S): Mus musculus

PROVIDER: GSE318951 | GEO | 2026/06/25

REPOSITORIES: GEO

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