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Targeting IGF2BP1 reverses immune evasion in CTL-enriched pancreatic cancer

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) remains poorly responsive to immune checkpoint therapy. To investigate tumor-intrinsic immune evasion mechanisms, we performed RNA-sequencing of the basal-like PANC-03.27 PDAC cell line following IGF2BP1 knockdown using pooled siRNAs. Transcriptome profiling revealed induction of interferon-γ signaling and downregulation of curated IGF2BP1 target transcripts, consistent with a conserved immunoregulatory program. Gene set enrichment analysis and STAT reporter assays confirmed activation of JAK/STAT-dependent pathways. These datasets provide a resource for understanding IGF2BP1-mediated transcriptional regulation in PDAC and for identifying potential targets to enhance anti-tumor immune responses.

ORGANISM(S): Homo sapiens

PROVIDER: GSE319148 | GEO | 2026/02/11

REPOSITORIES: GEO

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