Context-dependent effects of DHRS2 on cell-cycle progression, apoptosis and inflammatory gene expression in breast cell lines

ABSTRACT: Basal DHRS2 expression showed significant variation across different cell lines, with the highest levels observed in the non-tumorigenic MCF-10A. Silencing DHRS2 disrupted pathways such as ribosome biogenesis, DNA replication, and ion transport, whereas overexpression altered mitochondrial gene transcription and nucleoside synthesis. Loss of DHRS2 accelerated cell-cycle progression in MCF-7 and MCF-10A cells, whereas its overexpression induced G0/G1 phase arrest. Apoptosis levels increased with knockdown and decreased with overexpression, mainly in cancer cells. Inflammatory gene responses varied depending on cell type, particularly involving CASP1, IL-1A/B, and PYHIN1. Overexpression of DHRS2 promoted cell detachment and migration, suggesting cytoskeletal remodeling.

ORGANISM(S): Homo sapiens

PROVIDER: GSE322593 | GEO | 2026/09/22

REPOSITORIES: GEO