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Single-cell RNA-seq profiling of the DHT-induced androgenetic alopecia (AGA) mouse model treated with anti-DKK3 antibody

ABSTRACT: Androgenetic alopecia (AGA) is characterized by progressive hair follicle miniaturization and remodeling of the skin microenvironment. To investigate cellular changes associated with AGA and the effects of DKK3 blockade, we performed single-cell RNA sequencing (scRNA-seq) of dorsal skin from a DHT-induced mouse model. Three experimental groups of male C3H/HeN mice were analyzed: vehicle control, DHT-treated AGA model, and DHT-treated mice receiving anti-DKK3 neutralizing antibody. Single-cell transcriptomic profiling identified cell population changes associated with DHT exposure and their modulation by anti-DKK3 treatment. This dataset provides a single-cell atlas of dorsal skin in the AGA model and following DKK3 inhibition.

ORGANISM(S): Mus musculus

PROVIDER: GSE325671 | GEO | 2026/03/23

REPOSITORIES: GEO

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Single-cell RNA-seq profiling of the DHT-induced androgenetic alopecia (AGA) mouse model treated with anti-DKK3 antibody

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