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DIA proteomic profiling of dorsal skin from Dendrobium officinale polysaccharide-treated C57BL/6 mice

ABSTRACT: This project contains DIA-PASEF proteomics data generated from dorsal skin tissues of male C57BL/6 mice in a control group, a DHT-induced androgenetic alopecia (AGA) model group, and a Dendrobium officinale polysaccharide (DOP, 7.5 mg/mL)-treated group. The study was designed to investigate proteomic alterations associated with DHT-induced hair loss and the response to DOP treatment in vivo. After dose screening, 7.5 mg/mL DOP was selected for subsequent mechanistic studies, and skin tissues from the control, model, and DOP groups were subjected to quantitative proteomic analysis. Peptides were analyzed on a nanoElute2–timsTOF Pro2 platform in DIA-PASEF mode, and raw data were processed in Spectronaut using the Pulsar search engine against the reviewed Mus musculus UniProt database.

ORGANISM(S): Mus Musculus

SUBMITTER: Junwen Wang

PROVIDER: PXD077413 | iProX | Mon Apr 20 00:00:00 GMT+01:00 2026

REPOSITORIES: iProX

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Dendrobium officinale polysaccharide improves hair regrowth in androgenetic alopecia mice and is associated with coordinated changes in local steroid metabolism, ESR1 activation, and keratin-related follicular responses.

Ba Yuchen Y Wang Junen J Qi Lin L Liu Zheng Z Peng Dan D

Frontiers in pharmacology 20260518

<h4>Background</h4>Androgenetic alopecia (AGA) is characterized by androgen-dependent follicular miniaturization and progressive disturbance of follicular structure and cycling. Local steroid metabolism, including 5α-reductase-related androgen production and aromatase-related estrogen conversion, may contribute to this process.<h4>Methods</h4>A dihydrotestosterone (DHT)-induced mouse model of AGA was used to evaluate the <i>in vivo</i> effects of <i>Dendrobium officinale</i> polysaccharide (DOP) ...[more]

PMID: 42232180

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