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Epigenomic changes in chromatin accessibility following 1,25-dihydroxyvitamin D3 treatment in human endometrial stromal cells

ABSTRACT: Chromatin accessibility is a key determinant of gene regulation and cellular responsiveness to hormonal signaling. Although vitamin D has been implicated in diverse biological processes, its effects on chromatin accessibility in human endometrial stromal cells remain incompletely characterized. In this study, the impact of 1,25-dihydroxyvitamin D₃ on chromatin accessibility was examined using ATAC-seq. Overall, these findings indicate that 1,25-dihydroxyvitamin D₃ is associated with changes in chromatin accessibility in human endometrial stromal cells and suggest a potential epigenomic basis for vitamin D–mediated cellular responses.

ORGANISM(S): Homo sapiens

PROVIDER: GSE326063 | GEO | 2026/08/12

REPOSITORIES: GEO

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Epigenomic changes in chromatin accessibility following 1,25-dihydroxyvitamin D3 treatment in human endometrial stromal cells

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