Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic profiling of pancreatic islets in mice with ALIX deletion in PDGFRα⁺ mesenchymal progenitors under high-fat diet feeding

ABSTRACT: Using mice in which ALIX, a key regulator of small extracellular vesicle (sEV) biogenesis, was selectively deleted in PDGFRα⁺ mesenchymal progenitors (Pα-ALIXKO mice), we performed RNA sequencing of pancreatic islets isolated from control and Pα-ALIXKO mice under high-fat diet feeding. This dataset enables the analysis of transcriptomic changes in pancreatic islets derived from control and Pα-ALIXKO mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE326591 | GEO | 2026/08/31

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptomic profiling of ALIX knockout mesenchymal stem cells from subcutaneous white adipose tissues in mice under high-fat diet feeding

Project description:Cells throughout the body release small extracellular vesicles (sEVs), including exosomes, which function as modulators of metabolism. In this study, we performed RNA sequencing of mesenchymal stem cells (MSCs) derived from subcutaneous white adipose tissue isolated from control and Pα-ALIXKO mice, in which ALIX, a key regulator of sEV biogenesis, was selectively deleted in PDGFRα⁺ tissue-resident mesenchymal progenitors. Mice were subjected to high-fat diet feeding. This dataset enables the analysis of transcriptomic changes in MSCs derived from control and Pα-ALIXKO mice.

2026-08-31 | GSE326593 | GEO

Transcriptomic profiling of pancreatic islets in mice with ALIX deletion in PDGFRα⁺ mesenchymal progenitors under high-fat diet feeding

Project description:Transcriptomic profiling of pancreatic islets in mice with ALIX deletion in PDGFRα⁺ mesenchymal progenitors under high-fat diet feeding

| PRJNA1445972 | ENA

Global analyses of mouse pancreatic islets from high fat fed (HF) and ob/ob mice

Project description:Mouse pancreatic islets from obese mice

2015-04-01 | MSV000079093 | MassIVE

Ring1b profiling in pancreatic islets

Project description:To gain insights into how pancreatic cells are programmed in vivo, we profiled RNA expression in pancreatic islets of pancreatic Ring1b conditional KO mice (conditional using a pancreas specfic Cre; Pdx1-Cre) and their littermate controls

2013-02-10 | E-MTAB-1404 | biostudies-arrayexpress

Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic ?-cell function (Expression data from islets of control and Insm1 conditional deleted adult pancreatic islets)

Project description:The zinc finger factor Insm1 is known to regulate differentiation of pancreatic ? cells during development, Here we show that Insm1 is essential for the maintenance of functionally mature pancreatic ? cells in mice. We used microarrays to analyse the global gene expression after deletion of insm1 in adult pancreatic ? cells and identified functional important genes and immature islets releated genes deregulated in the mutatant islets. We used 8 mutant and 8 litter matched control mice for the islets preparation.

2015-03-31 | E-GEOD-54044 | biostudies-arrayexpress

Identification of Nkx6.1 regulated genes in mature pancreatic islets.

Project description:Nkx6.1 target genes were identified in mature pancreatic islets by comparing gene expression in conditional Nkx6.1-ablated islets versus control islets using microarray analysis. Nkx6.1 was conditionally ablated in mature pancreatic islets by recombination of a Nkx6.1-flox allele using the tamoxifen-inducible Pdx1-CreERTM allele (Gu et al 2002). Mice were injected with 2 mg/25 g tamoxifen in corn oil four times between 4 and 6 weeks of age. Islets were isolated after the final tamoxifen injection. Total RNA was isolated and pooled from pancreata of 6 week old Nkx6.1fl/-;Pdx1-CreERTM (mutant) versus Nkx6.1fl/+;Pdx1-CreERTM (control) littermates for 3 biological replicates.

2013-09-12 | E-GEOD-40470 | biostudies-arrayexpress

Inflammatory profile of NOD.Batf3-/- islets

Project description:NOD mice deficient in the transcription factor Batf3 never develop diabetes. The goal of this study was to determine if NOD.Batf3-/- mice islets had any inflammatory signature associated with type 1 diabetes. Islets of Langerhans were isolated from NOD, NOD.Batf3-/-, and NOD.Rag1-/- and then compared to determine inflammatory gene profiles. At 6 and 8 weeks of age, NOD.Batf3-/- islets had an absence of inflammatory gene expression and were almost identical to uninflamed NOD.Rag1-/- islets. This work shows that absence of the Batf3 transcription factor is sufficient to prevent all the inflammatory sequelae of autoimmune diabetes. RNA was isolated from the pancreatic islets of Langerhans of 27 experimental mice. Mice were aged either 6 or 8 weeks. Three genotypes were tested: NOD, NOD.Rag1-/-, and NOD.Batf3-/-. There were 3-6 biological replicates per condition. All mice were female. All data was normalized using RMA in Arraystar.

2014-09-29 | E-GEOD-61847 | biostudies-arrayexpress

Genome-wide chromatin accessibility of founder mice pancreatic islets

Project description:ATAC-seq data of founder mice pancreatic islets

2021-07-27 | GSE180363 | GEO

scRNA-seq of pancreatic islets from control and Haster-pKO mice

Project description:Pancreas specific deletion of the Haster promoter region results in a variegated phenotype in pancreatic islets with overexpression or silencing of the Hnf1a gene. To determine the transcriptional consequence of the overexpression or silencing of Hnf1a is islet cells from the Haster pKO mice (Haster loxP/loxP;Pdx1-Cre), we performed scRNA-seq of pancreatic islets from control and adult female Haster pKO mice.

2022-05-01 | E-MTAB-11477 | biostudies-arrayexpress

Founder mice pancreatic islets and beta cells

Project description:Founder mice pancreatic islets and beta cells

| PRJNA749601 | ENA