Single-cell RNA-seq profiles of intestinal mucosa in IBS-D rats to explore the mechanism of immune barrier regulation in pathogenesis

ABSTRACT: We have employed a single cell sequencing approach using 10x Genomics scRNAseq to study isolated endothelial cells, immune cells and stromal cells from the intestinal mucosa of the control group and diarrhea-predominant irritable bowel syndrome (IBS-D) rats. This study systematically deciphered the transcriptional landscape of the colonic mucosa in a rat model of IBS-D at single-cell resolution, revealing compositional shifts, transcriptional signatures, and potential regulatory networks among various cellular subpopulations, including epithelial, immune, and stromal cells.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE326856 | GEO | 2026/07/08

REPOSITORIES: GEO