Spatial transcriptomics links hippocampal synaptic remodeling to microglial phagocytosis in synucleinopathy

ABSTRACT: Synucleinopathies, including Parkinson’s disease and Lewy body dementia, show region-specific vulnerability across the brain, but the molecular basis of selective regional involvement remains incompletely understood. We performed spatial transcriptomic profiling of brain sections from 6-month-old G2-3 alpha-synuclein transgenic mice and wild-type littermates using the 10x Genomics Visium Spatial Gene Expression platform to characterize region-specific transcriptional alterations associated with alpha-synuclein pathology. This dataset provides a resource for investigating spatially resolved molecular changes in the synucleinopathy mouse brain.

ORGANISM(S): Mus musculus

PROVIDER: GSE326942 | GEO | 2026/04/08

REPOSITORIES: GEO