Spatial transcriptomics of IRF7-dependent pathway in chronic lung allograft dysfunction

ABSTRACT: Chronic lung allograft dysfunction (CLAD) remains a major barrier to long-term survival after lung transplantation. This study investigates the role of the type I interferon master regulator IRF7 in virus-induced airway fibrogenesis. Using NanoString GeoMx digital spatial profiling, we performed whole transcriptome spatial analysis of human lung tissue from CLAD, non-CLAD transplant, and non-transplanted normal donor lungs to characterize the spatial gene expression landscape associated with IRF7-dependent fibrotic pathways.

ORGANISM(S): Homo sapiens

PROVIDER: GSE326968 | GEO | 2026/04/08

REPOSITORIES: GEO