Semaglutide Slows Epigenetic Aging in a Randomized Trial of HIV-Associated Lipohypertrophy

ABSTRACT: Genome-wide DNA methylation profiling of PBMC samples from people living with HIV HIV-1 infection impacts biological aging, and epigenetic clocks highlight epigenetic age acceleration in people with HIV. Despite evidence indicating Glucagon-like peptide-1 receptor agonist in beneficial HIV-associated cardiometabolic outcomes, effects on aging biomarkers in HIV epigenetic studies is a major gap in knowledge. Hence, we generated a representative epigenetic dataset to examine Glucagon-like peptide-1 receptor agonist in epigenetic ageing and relationships to clinical phenotypes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE327270 | GEO | 2026/04/17

REPOSITORIES: GEO