Spatially resolved, integrated single-cell multiomic profiling of the transcriptome and epigenomic targets in frozen tissue sections

ABSTRACT: We present a spatial Trekker–CUT&Tag multiome protocol that combines direct spatial barcoding of a frozen tissue section with subsequent single-cell multiome analysis. This approach enables integrated single-cell and spatial profiling of histone H3K27ac modification and gene expression, revealing mechanistic and anatomical cell-type organization across the tissue.

ORGANISM(S): Mus musculus

PROVIDER: GSE327406 | GEO | 2026/05/31

REPOSITORIES: GEO