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Single-cell RNA sequencing reveals that Epac1 deletion attenuates Müller glial pathological activation in ischemia-induced retinopathy

ABSTRACT: Here we report the single-cell RNA sequencing (scRNA-seq) analysis of retinas from WT and Epac1-knockout mice under Oxygen-Induced Retinopathy (OIR) and Room Air (RA) conditions. The OIR model was induced by exposing pups to 70% oxygen from postnatal day 7 (P7) to P12. This study aims to delineate the cellular heterogeneity and investigate the neuroprotective mechanisms associated with Epac1 deletion, with a specific focus on Müller glial pathological activation and retinal neurodegeneration. Retinal tissues were collected at postnatal day 17 (P17) to establish a comprehensive transcriptomic profile of the ischemia-induced retinopathy model.

ORGANISM(S): Mus musculus

PROVIDER: GSE328096 | GEO | 2026/04/15

REPOSITORIES: GEO

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