Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression data from white adipose tissue (WAT) treated with Vigna Umbellata extract (VE)

ABSTRACT: Gene expression profiling reveals DEGs in WAT We evaluated the effects of Vigna Umbellata on WAT of ob/ob mice through an untargeted whole-genome transcriptome analysis

ORGANISM(S): Mus musculus

PROVIDER: GSE328286 | GEO | 2026/07/02

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	GSE328286_RAW.tar	Raw
	GSE328286_processed_data_wat.xlsx	Xlsx
	filelist.txt	Txt

Items per page:

1 - 4 of 4

Similar Datasets

Gene expression data from liver treated with Vigna Umbellata extract (VE)

Project description:Gene expression profiling reveals DEGs in liver. We evaluated the effects of Vigna Umbellata on liver of ob/ob mice through an untargeted whole-genome transcriptome analysis.

2026-07-02 | GSE328284 | GEO

Gene Expression in the BAT and WAT of ob/ob and ob/ob/Cidea-/-/Cidec-/- mice

Project description:ob/ob mice is an obese mice. CIDE family proteins including Cidea, Cideb and Cidec play important role in lipid metabolism. Cidea is mainly expressed in the brown adipose tissue (BAT). Cidec is mainly expressed in the BAT and white adipose tissue (WAT). We generated ob/ob/Cidea-/-/Cidec-/- mice to investigate the phenotype of fat tissue. ob/ob/Cidea-/-/Cidec-/- mice are lean when compared with ob/ob mice. The tissue weight and TAG content of BAT and WAT was extreamly decreased in ob/ob/Cidea-/-/Cidec-/- mice compared with that in ob/ob mice. We next extract the total RNA from the BAT and WAT of ob/ob and ob/ob/Cidea-/-/Cidec-/- mice, to perform microarray analysis using Mouse Gene 1.0 ST array system, Affymetrix. We then analysised the up-regulated and down regulated pathways.

2018-04-18 | GSE100989 | GEO

Protective effect of Vigna unguiculata extract against aging and neurodegeneration

Project description:Aging and age-related neurodegeneration are among the major challenges because of the progressive increase in the number of elder people in the wold population. Nutrition, which has important long-term consequences for health, is actually considered a means to prevent diseases and to reach a healthy aging. Here we investigate the role of Vigna unguiculata beans on senescence by using Saccharomyces cerevisiae and Drosophila melanogaster as model systems. Aqueous extract, mainly containing starch, proteins and amino acids, extends chronological lifespan in yeast cells, showing a remarkable synergistic effect in combination with caloric restriction. The extension of yeast longevity requires both the anti-aging Snf1/AMPK and the pro-aging Ras2/PKA pathways. A significant marked increase of lifespan was observed also in fruit flies supplemented with the V. unguiculata extract, which is accompanied by the increased expression of FOXO, NOTCH, SIRT1 and heme oxygenase (HO) genes, already known to be required for the extension of fruit fly longevity. α-synuclein forms toxic intracellular protein inclusions in Parkinson’s disease (PD) and actually preventing α-synuclein self-assembly has become one of the most promising approaches for the treatment of this neurodegenerative disorder. Here, we report that in vitro aggregation of -synuclein, as well as its toxicity in yeast and in neuroblastoma cells, are strongly decreased in the presence of bean extract. In addition, in a Caenorhabditis elegans model of PD that expresses α-synuclein, Vigna unguiculate extract substantially reduces the number of the age-dependent degeneration of the cephalic dopaminergic neurons. Overall, our data support the role of Vigna unguiculata beans as a functional food, worth to be further explored in order to develop lead molecules for therapeutic intervention in age-related disorders.

2021-09-08 | PXD017716 | Pride

Differential gene expression between female hNAG-1 transgenic and Wt mice in abdominal white adipose tissue (WAT)

Project description:To understand the mechanism of extended lifespan in hNAG-1 mice, we used whole genome microarray analysis to examine differential gene expression in abdominal WAT in hNAG-1 mice. Differential category expression analysis may show significant differences between hNAG-1 mice and WT mice in key pathways in the regulation of metabolism and mammalian lifespan. In addition, To explore the reason why hNAG-1 mice are leaner than Wt littermates. A total of 6 animals from each genotype were used and WAT was extacted from each mouse, we then pooled two sample as one sample for each genotype to be used in microarray experiment.

2015-08-10 | E-GEOD-60614 | biostudies-arrayexpress

Single cell functional genomics reveals plasticity of subcutaneous white adipose tissue (WAT) during early postnatal development

Project description:We performed a large-scale single cell transcriptomic (scRNA-seq) and epigenomic (snATAC-seq) characterization of cellular subtypes (adipose stromal cells (ASC) and adipocyte nuclei) during inguinal WAT (subcutaneous; iWAT) development in mice, capturing the early postnatal period (postnatal days (PND) 06 and 18) through adulthood (PND56).

2021-09-08 | GSE180589 | GEO

Transcription profiling of Ercc1 white adipose tissue

Project description:Transcriptome analysis of epididymal white adipose tissue (WAT) depots in Ercc1 animals: To further elucidate the role of ERCC1 in WAT we scanned the transcriptome of 15 day old wt and Ercc1 epididymal WAT.

2013-11-04 | E-MEXP-3930 | biostudies-arrayexpress

Differential gene expression between female hNAG-1 transgenic and Wt mice in abdominal white adipose tissue (WAT)

2015-08-10 | GSE60614 | GEO

Expression data from white and brown adipose tissue (WAT and BAT) of per2-/- and control mice

Project description:We found that the circadian protein PER2 interacts with the nuclear receptor PPARgamma to repress its activity. PPARgamma is a master regulator of adipogenesis and lipid metabolism and is very abundant in adipose tissue. We used microarrays to detail the global program of gene expression in adipose tissue lacking the per2 gene. This analysis identified several PPARgamma target genes up-regulated in adipose tissue from per2-/- mice. Per2-/- and per2+/+ male mice (Bae et al., 2001) were housed under 12 hr light/12 hr dark (LD) cycles. Mice 20 weeks old were sacrificed at the same time and adipose tissue (WAT and BAT) was collected for RNA extraction. 3 biological replicates per mouse/tissue.

2010-10-19 | E-GEOD-20165 | biostudies-arrayexpress

Escherichia coli strain:WAT

Project description:Escherichia coli WAT genome

| PRJNA292047 | ENA

Transcriptomal comparison between group 2 innate lymphoid cells (ILC2s) in the murine small intestine (SI-ILC2s) and those in white adipose tissue (WAT-ILC2s)

Project description:Transcriptomal comparison between group 2 innate lymphoid cells (ILC2s) in the murine small intestine (SI-ILC2s) and those in white adipose tissue (WAT-ILC2s).

2019-07-02 | GSE130530 | GEO