Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression data from liver treated with Vigna Umbellata extract (VE)

ABSTRACT: Gene expression profiling reveals DEGs in liver. We evaluated the effects of Vigna Umbellata on liver of ob/ob mice through an untargeted whole-genome transcriptome analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE328284 | GEO | 2026/07/02

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	GSE328284_RAW.tar	Raw
	GSE328284_processed_data_liver.xlsx	Xlsx
	filelist.txt	Txt

Items per page:

1 - 4 of 4

Similar Datasets

Gene expression data from white adipose tissue (WAT) treated with Vigna Umbellata extract (VE)

Project description:Gene expression profiling reveals DEGs in WAT We evaluated the effects of Vigna Umbellata on WAT of ob/ob mice through an untargeted whole-genome transcriptome analysis

2026-07-02 | GSE328286 | GEO

Protective effect of Vigna unguiculata extract against aging and neurodegeneration

Project description:Aging and age-related neurodegeneration are among the major challenges because of the progressive increase in the number of elder people in the wold population. Nutrition, which has important long-term consequences for health, is actually considered a means to prevent diseases and to reach a healthy aging. Here we investigate the role of Vigna unguiculata beans on senescence by using Saccharomyces cerevisiae and Drosophila melanogaster as model systems. Aqueous extract, mainly containing starch, proteins and amino acids, extends chronological lifespan in yeast cells, showing a remarkable synergistic effect in combination with caloric restriction. The extension of yeast longevity requires both the anti-aging Snf1/AMPK and the pro-aging Ras2/PKA pathways. A significant marked increase of lifespan was observed also in fruit flies supplemented with the V. unguiculata extract, which is accompanied by the increased expression of FOXO, NOTCH, SIRT1 and heme oxygenase (HO) genes, already known to be required for the extension of fruit fly longevity. α-synuclein forms toxic intracellular protein inclusions in Parkinson’s disease (PD) and actually preventing α-synuclein self-assembly has become one of the most promising approaches for the treatment of this neurodegenerative disorder. Here, we report that in vitro aggregation of -synuclein, as well as its toxicity in yeast and in neuroblastoma cells, are strongly decreased in the presence of bean extract. In addition, in a Caenorhabditis elegans model of PD that expresses α-synuclein, Vigna unguiculate extract substantially reduces the number of the age-dependent degeneration of the cephalic dopaminergic neurons. Overall, our data support the role of Vigna unguiculata beans as a functional food, worth to be further explored in order to develop lead molecules for therapeutic intervention in age-related disorders.

2021-09-08 | PXD017716 | Pride

Gene expression data from 3D spheroids of human amniotic epithelial stem cell (hAESC) treated with Tsuruazuki Extract (Tsuru)

Project description:Gene expression profiling reveals mesoderm lineage-specific genes were more significantly regulated with the most prominent regulated DEGs were identified in adipose tissue. We evaluated the effects of Tsuruazuki extract on human amniotic epithelial stem cells. We performed an untargeted whole-genome transcriptome analysis to explore functionality of Tsuru in a stem cell-based tool.

2024-09-30 | GSE278052 | GEO

Mung bean (Vigna radiata L.) ethanol extracts alleviate alcoholic liver injury with modulation of gut microbiota and spermidine elevation

Project description: The pathophysiology of alcoholic-associated liver disease (ALD) is multifaceted. Utilizing the gut-liver axis framework and integrated multi-omics approaches, this study systematically evaluated the therapeutic potential of mung bean (Vigna radiata L.) ethanol extracts (MBE) in ALD, and its regulatory effects on gut microbiota and serum metabolites. Chemical analysis identified vitexin, isovitexin, catechin, trigonelline, and caffeic acid as MBE’s primary bioactive compounds. In a modified NIAAA model, MBE alleviated liver injury, lipid dysregulation, inflammation, oxidative stress, and gut barrier damage via PPARα-mediated lipid metabolism and Nrf2-driven antioxidant activation. 16S rRNA sequencing and in vitro fermentation experiment revealed that MBE specifically enriched Lactobacillus johnsonii in vivo and promoted its growth in vitro, with this bacterium being closely associated with increased spermidine levels. Lactobacillus johnsonii supplementation replicated MBE’s hepatoprotection by increasing spermidine and mitigating alcohol-induced hepatic/intestinal damage. Subsequent in vivo and in vitro spermidine interventions further validated its hepatoprotection. These findings propose a novel “MBE-Lactobacillus johnsonii-spermidine-liver” regulatory mode, positioning MBE as a dietary or therapeutic candidate for ALD and offering gut-liver axis targets.

2025-10-10 | MTBLS13109 | MetaboLights

Targeted metabolomics of liver after FGF1 injection

Project description:We have performed measured levels of metabolites involved in gluconeogenesis in liver. Over-night fasted ob ob mice that were injected with vehicle or FGF1 for 2h were used for the analysis.

2021-11-11 | MSV000088351 | MassIVE

RNA-seq analysis of multiple tissues in wild mung bean (Vigna radiata var. sublobata)

Project description:This study presents transcriptome profiles of multiple tissues (root, stem, leaf, flower, and pod) from Vigna radiata var. sublobata, a wild relative of cultivated mung bean. RNA sequencing was performed using Illumina platform to investigate tissue-specific gene expression patterns. The data will facilitate understanding of gene regulation in different plant organs and provide resources for comparative genomics with cultivated Vigna radiata. Experimental design: Tissues were collected from mature plants grown under controlled conditions. Three biological replicates per tissue type. Libraries were prepared using poly-A selection and sequenced in paired-end mode (2x150 bp). This submission includes raw sequencing data (FASTQ files) for all samples.

2026-01-13 | E-MTAB-16409 | biostudies-arrayexpress

Vigna

Project description:Vigna Genome Project

| PRJDB7727 | ENA

Bradyrhizobium japonicum proteomic reference map, and Vigna mungo leaf proteome map

Project description:DISCLAIMER: This project actually contains two separate and independent assays by mistake. They should be not be considered together.Assay 9769 - Bradyrhizobium japonicum proteomic reference map PMID : 20806226Assay 15318 - Vigna mungo leaf proteome map PMID : 23587433

2011-11-15 | PRD000119 | Pride

Vigna subterranea

Project description:Vigna subterranea Variation

| PRJNA355232 | ENA

Vigna stipulacea

Project description:Vigna stipulacea overview

| PRJNA1297840 | ENA