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Catechol-O-methyltransferase attenuates invasive potential by upregulating desmogleins and is associated with better prognosis in ovarian cancer

ABSTRACT: Catechol-O-methyltransferase (COMT) is a key enzyme in estrogen catabolism, but its estrogen-independent roles in ovarian cancer remain largely unknown. This study aims to elucidate the molecular mechanisms by which COMT suppresses cell invasion and to evaluate its significance as a prognostic marker. We performed transcriptome analysis (RNA-seq) on ovarian cancer cells to identify downstream targets of COMT. Our results show that COMT overexpression significantly inhibits cell invasion in an estrogen-independent manner. Integrative analysis of RNA-seq and CE-MS metabolome data revealed that COMT upregulates desmoglein genes (DSG1-3), thereby strengthening cell-to-cell contact, and induces metabolic remodeling. These findings suggest that COMT suppresses metastasis by regulating cell adhesion and metabolism, serving as a potential prognostic marker and therapeutic target in ovarian cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE330672 | GEO | 2026/05/26

REPOSITORIES: GEO

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