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Spp1 Mediates Antimony Trioxide-Induced Male Reproductive Toxicity via Regulating Inflammatory Response and Blood-Testis Barrier Integrity

ABSTRACT: This study investigated the male reproductive toxicity of antimony trioxide (Sb₂O₃) using in vivo male mice and in vitro TM4 Sertoli cell models. Sb₂O₃ exposure impaired spermatogenesis, triggered inflammatory responses, and disrupted blood-testis barrier integrity by upregulating Spp1, whereas Spp1 knockdown effectively alleviated Sb₂O₃-induced inflammation, cell migration dysfunction and tight junction protein loss, identifying Spp1 as a crucial regulator of Sb₂O₃-mediated male reproductive injury.

ORGANISM(S): Mus musculus

PROVIDER: GSE330989 | GEO | 2026/08/05

REPOSITORIES: GEO

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Spp1 Mediates Antimony Trioxide-Induced Male Reproductive Toxicity via Regulating Inflammatory Response and Blood-Testis Barrier Integrity

Project description:Spp1 Mediates Antimony Trioxide-Induced Male Reproductive Toxicity via Regulating Inflammatory Response and Blood-Testis Barrier Integrity

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Alterations in MAPK Signaling in Alveolar Bronchiolar Carcinomas from B6C3F1/N Mice Exposed to Antimony Trioxide by Inhalation for 2 Years

Project description:To identify transcripts differentially expressed between control samples and spontaneous tumors, or control samples and antimony treated lung tumors, we collected RNA from male and female B6C3F1 mice from a 2-year inhalation NTP bioassay exposed to 0 to 30 mg/m3 antimony trioxide. These samples were interrogated with the Affymetrix Mouse Genome 430 2.0 GeneChip Array. A total of 9941 gene transcripts were differentially expressed between control samples and spontaneous tumors, and 12441 gene transcripts were differentially expressed between control samples and treated antimony tumors (false discovery rate (FDR) < 0.05).

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High antimony resistance strain Enterobacter sp. Z1 mediates biomineralization of antimony trioxide

Project description:Enterobacter sp. Z1 showed resistance to antimony and strong ability to produce antimony trioxide (Sb2O3) minerals. Thus, so the purpose of this project is to clarify mechanism of the biomineralization in strain Z1.

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Effects of arbuscular mycorrhizal fungi on Pteris cretica L var. nervosa fronds antimony enrichment, morphology and proteome changes during antimony phytoremediation

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Project description:The mRNA expression of antimony resistant strains of Leishmania donovani was compared to the expression of the sensitive Leishmania donovani. The antimony resistant and sensitive Leishmania donovani were grown in complete M199 medium with 10% FCS and Penicillin streptomycin mixture. At stationary phase (5 day culture) cells were harvested in sterile Phosphate buffered saline and used for RNA isolation.

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Transcriptional analysis of Leishmania infantum antimony resistant strains using full-genome DNA microarrays

Project description:The aim of the experiment is to detect any gene expression modulation in an antimony resistant L.infantum Sb2000.1 strain compared to an antimony sensitive L.infantum WT strain. We want to identify the modulated genes associated with an antimony resistant phenotype. The Sb2000.1 resistant strain used is about 1000 times more resistant to SbIII than the WT sensitive strain. The full-genome DNA microarrays includes one 70-oligonucleotide probe for each gene of L. infantum. Keywords: drug resistance

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