Transcriptomics

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A skull bone marrow-glymphatic-brain axis mediates CD8 T cell trafficking and involvement in post-ischemic stroke injury 01


ABSTRACT: Here, we identify a skull bone marrow (SBM)-glymphatic-brain axis that mediates the trafficking and delivery of cytotoxic CD8 T cells into the ischemic brain parenchyma in human AIS. Single-cell transcriptomic profiling of patients with AIS identifies the SBM as a dynamically responsive CD8 T cell reservoir that is transcriptionally distinct from peripheral blood.

ORGANISM(S): Homo sapiens

PROVIDER: GSE331114 | GEO | 2026/05/20

REPOSITORIES: GEO

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