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TRPV1–STAT3 signaling as a driver of lethal pathology during pneumococcal nose-to-brain invasion

ABSTRACT: To investigate mechanisms underlying lethal pneumococcal nose-to-brain infection, we established a murine intranasal Streptococcus pneumoniae infection model with methimazole-induced olfactory epithelial injury and/or resiniferatoxin-mediated trigeminal TRPV1 ablation. Spatial transcriptomic analysis identified a distinct inflammatory transcriptional cluster localized to the olfactory epithelium and adjacent olfactory bulb in methimazole-treated mice. The cluster showed enrichment of STAT3-associated transcriptional programs and inflammatory pathways. These findings suggest that olfactory epithelial injury and trigeminal TRPV1 signaling contribute to localized inflammatory responses during pneumococcal nose-to-brain invasion.

ORGANISM(S): Mus musculus

PROVIDER: GSE331225 | GEO | 2026/08/19

REPOSITORIES: GEO

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