Transcriptome of mouse colon under radiation injury and syringin treatment

ABSTRACT: This study performed transcriptome RNA sequencing on 15 mouse colon samples, including 5 blank control samples, 5 abdominal ionizing radiation (IR)-induced intestinal injury samples, and 5 syringin-treated injury samples. The aim was to identify gene expression changes and key regulatory pathways involved in radiation-induced intestinal damage and the protective mechanism of syringin. Differentially expressed genes (DEGs) were analyzed to explore mechanisms related to ferroptosis, the hnRNPA3-ESRRG-AIFM2-FSP1 regulatory axis, and gut-brain axis communication. These data provide a valuable transcriptomic resource for understanding radiation-induced intestinal injury and the transcriptomic responses to syringin in mouse colon tissue.

ORGANISM(S): Mus musculus

PROVIDER: GSE332752 | GEO | 2026/09/03

REPOSITORIES: GEO