Cystine Restriction Alleviates T Cell Exhaustion and Enhances CAR-T Cell Potency

ABSTRACT: This study was designed to explore how targeting Slc7a11 affected CD8+ T cell differentiation and function using a mouse colorectal cancer model. Single-cell RNA-seq was used to monitor tumor-infiltrating CD8+ T cells from Slc7a11 knockout and wild-type mouse tumor models treated with IgG control or anti-Ctla4 antibody.

ORGANISM(S): Mus musculus

PROVIDER: GSE333187 | GEO | 2026/07/18

REPOSITORIES: GEO