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Cystine Restriction Alleviates T Cell Exhaustion and Enhances CAR-T Cell Potency

ABSTRACT: This study was designed to explore how targeting Slc7a11 affected CD8+ T cell differentiation and function using a mouse colorectal cancer model. TCR-seq was used to profile T cell receptor repertoires in mouse tumor-infiltrating T cells from wild-type and Slc7a11 knockout tumor models treated with IgG control or anti-Ctla4 antibody.

ORGANISM(S): Mus musculus

PROVIDER: GSE333188 | GEO | 2026/07/18

REPOSITORIES: GEO

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Cystine Restriction Alleviates T Cell Exhaustion and Enhances CAR-T Cell Potency

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