Dataset Information


In vivo genome-wide chromatin immunoprecipitation for the chondrogenic transcription factors, Sox9, Sox5 and Sox6

ABSTRACT: Tissue ChIP-seq was performed on transcription factor Sox5, Sox6 and Sox9 using limbs and tails from E13.5 mouse embryos to find their in vivo binding sites in the genome Overall design: Sox9 and Sox6 ChIP-seq was performed on wildtype mice whereas Sox5 ChIP-seq was done using transgenic wildtype mice.

INSTRUMENT(S): Illumina Genome Analyzer II (Mus musculus)

SUBMITTER: Thomas Lufkin  

PROVIDER: GSE33419 | GEO | 2017-06-15



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An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos.

Lee Wenqing Jean WJ   Chatterjee Sumantra S   Yap Sook Peng SP   Lim Siew Lan SL   Xing Xing X   Kraus Petra P   Sun Wenjie W   Hu Xiaoming X   Sivakamasundari V V   Chan Hsiao Yun HY   Kolatkar Prasanna R PR   Prabhakar Shyam S   Lufkin Thomas T  

BioMed research international 20170528

Embryogenesis is an intricate process involving multiple genes and pathways. Some of the key transcription factors controlling specific cell types are the Sox trio, namely, Sox5, Sox6, and Sox9, which play crucial roles in organogenesis working in a concerted manner. Much however still needs to be learned about their combinatorial roles during this process. A developmental genomics and systems biology approach offers to complement the reductionist methodology of current developmental biology and  ...[more]

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