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Mapping vascular plasticity in liver fibrogenesis identifies novel fibrosis-associated endothelial cells in early-stage liver disease

ABSTRACT: Vascular plasticity is a crucial biological asset enabling our bodies to rapidly adapt to infections and acute inflammation. However, repeated insult during chronic disease can result in these vascular adaptations becoming irreversible, thereby driving disease progression and fibrosis. This study aimed to understand if phenotypic changes in endothelial cell (EC) identity could be indicative of progressive fibrosis and thereby offer new diagnostic and therapeutic opportunities for patients with metabolic dysfunction-associated steatotic liver disease (MASLD).

ORGANISM(S): Homo sapiens

PROVIDER: GSE334308 | GEO | 2026/07/10

REPOSITORIES: GEO

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Transcriptomic profiles of liver biopsies in obese patients with metabolic dysfunction-associated steatotic liver disease

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