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Brain corticogenesis promotes SARS-CoV-2 neuro-glial tropism through lipid-dependent viral replication

ABSTRACT: Human induced pluripotent stem cell (hIPSC)-derived cerebral organoids (CBOs) provide a potential in-vitro model to study cellular composition and transcriptional dynamics during human brain development. This single-cell RNA analysis aims to evaluate the capacity of CBOs to reflect key brain developmental stages, assess their transcriptional fidelity against human fetal brain references, and characterize lipid metabolic gene programs associated with brain maturation, collectively providing a transcriptomic framework for understanding coordinated molecular and cellular changes during human brain development.

ORGANISM(S): Homo sapiens

PROVIDER: GSE334412 | GEO | 2026/06/10

REPOSITORIES: GEO

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	GSE334412_CBO_EB60and120_annotated_seurat_object.rds	Other
	GSE334412_RAW.tar	Raw
	filelist.txt	Txt

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