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Alternative splicing- and gene fusion-derived neoepitopes in MASLD-associated hepatocellular carcinoma

ABSTRACT: Metabolic dysfunction-associated steatotic liver disease (MASLD)-driven hepatocellular carcinoma (HCC) exhibits reduced responsiveness to immune checkpoint blockade compared with viral or other etiologies, suggesting underlying differences in tumor immunogenicity and immune evasion. To characterize the immunogenic landscape of MASLD-driven HCC, we profiled transcriptomic data from 120 liver tissue samples, including healthy controls (n = 12), MASLD samples (n = 13), and MASLD-associated HCC samples (n = 95), and investigated the contribution of transcriptome-derived neoantigens to this altered immune landscape, focusing on alternative splicing and gene fusion events as non-canonical sources of tumor-specific epitopes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE334651 | GEO | 2026/06/10

REPOSITORIES: GEO

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Effects of D4-MASLD and D5-MASLD Diets on Rats: Pathway Alterations Similar to Human MASLD

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