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Tumor-derived exosomal METTL3 reprograms macrophages through the m6A–IGF2BP2–ATG2A axis to promote lung adenocarcinoma stemness and brain metastasis

ABSTRACT: Lung adenocarcinoma (LUAD) brain metastasis remains a major clinical challenge, yet how tumor-derived exosomes remodel macrophage states to support metastatic colonization is incompletely understood.

ORGANISM(S): Homo sapiens

PROVIDER: GSE335637 | GEO | 2026/06/23

REPOSITORIES: GEO

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